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2025, 37(1): 1-11.
doi: 10.21147/j.issn.1000-9604.2025.01.01
Abstract
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Abstract:
ObjectiveNeuroblastoma is the most common extracranial solid tumor in children and has complex genetic underpinnings. Previous genome-wide association studies (GWASs) have identified many loci associated with neuroblastoma susceptibility; however, th...
2025, 37(1): 12-27.
doi: 10.21147/j.issn.1000-9604.2025.01.02
Abstract:
ObjectiveThe neglect of occult lymph nodes metastasis (OLNM) is one of the pivotal causes of early non-small cell lung cancer (NSCLC) recurrence after local treatments such as stereotactic body radiotherapy (SBRT) or surgery. This study aimed to deve...
2025, 37(1): 28-47.
doi: 10.21147/j.issn.1000-9604.2025.01.03
Abstract:
ObjectiveEarly predicting response before neoadjuvant chemotherapy (NAC) is crucial for personalized treatment plans for locally advanced breast cancer patients. We aim to develop a multi-task model using multiscale whole slide images (WSIs) features...
2025, 37(1): 48-65.
doi: 10.21147/j.issn.1000-9604.2025.01.04
Abstract:
ObjectiveRecurrence continues to be a pivotal challenge among hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2−) breast cancers. In the international consensus guidelines, HR+/HER2− breast cancer relapse pattern...
2025, 37(1): 66-72.
doi: 10.21147/j.issn.1000-9604.2025.01.05
Abstract:
ObjectiveThe trial was designed to evaluate the efficacy of prophylactic hyperthermic intraperitoneal chemotherapy (HIPEC) with cisplatin for patients with locally advanced gastric cancer (LAGC). MethodsBetween March 2015 and November 2016, a phase II...
2025, 37(1): 73-89.
doi: 10.21147/j.issn.1000-9604.2025.01.06
Abstract:
ObjectiveThe expression of programmed death 1 (PD-1) on CD8+ T cells is associated with their activation and exhaustion, while CD57 serves as a senescence marker. The impact of PD-1+ and CD57+CD8+ T cells on the prognosis of patients with advanced hi...
2025, 37(1): 90-114.
doi: 10.21147/j.issn.1000-9604.2025.01.07
Abstract:
ObjectiveProstate cancer (PCa) is a complex disease characterized by diverse cellular ecosystems within the tumor microenvironment (TME) and high tumor heterogeneity, which challenges clinically stratified management and reinforces the need for novel...
2025, 37(1): 115-117.
doi: 10.21147/j.issn.1000-9604.2025.01.08
Abstract:
The latest data from the NATALEE trial showed the absolute 3-year invasive disease-free survival benefit was 4.9% between the experimental and control groups. That is to say, in the intermediate-risk hormone receptor positive/human epidermal growth f...
The latest data from the NATALEE trial showed the absolute 3-year invasive disease-free survival benefit was 4.9% between the experimental and control groups. That is to say, in the intermediate-risk hormone receptor positive/human epidermal growth f...
2025, 37(1): 118-118.
doi: 10.21147/j.issn.1000-9604.2025.01.09
Abstract:
