2024 Vol.36(4)

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Original Article
Tumor-derived DEFB1 induces immune tolerance by inhibiting maturation of dendritic cell and impairing CD8+ T cell function in esophageal squamous cell carcinoma
Jingjing Duan, Haotian Wang, Minglu Liu, Yin Chen, Ning Li, Jieqiong Liu, Lingxiong Wang, Lin Li, Yaru Liu, Pengfei Dong, Xiuxuan Wang, Zhongyi Fan, Shunchang Jiao
2024, 36(4): 351-367. doi: 10.21147/j.issn.1000-9604.2024.04.01
Abstract(2341) FullText HTML (1448) PDF 10129KB(91)
Abstract:
ObjectiveCD8+ T cells are the key effector cells in the anti-tumor immune response. The mechanism underlying the infiltration of CD8+ T cells in esophageal squamous cell carcinoma (ESCC) has not been clearly elucidated.MethodsFresh ESCC tissues were ...
A pilot clinical study to evaluate feasibility of using single patient classifier as a prognostic test in stage II−III gastric cancer patients
Ji Yeong An, Sung Eun Oh, Soomin Ahn, Hyoung-II Kim, Yoo Min Kim, Minah Cho, Keun Won Ryu, Hong Man Yoon, Young Kyu Park, In Gyu Kwon, Sung Hoon Noh, Kyung Hee Lee, In Cho, Myoung Won Son, Jong Won Kim, Young-Woo Kim
2024, 36(4): 368-377. doi: 10.21147/j.issn.1000-9604.2024.04.02
Abstract(1829) FullText HTML (1242) PDF 2097KB(33)
Abstract:
ObjectivePrecision medicine approaches emphasize the importance of reliable prognostic tools for guiding individualized therapy decisions. In this study, we evaluated the clinical feasibility of the single patient classifier (SPC) test, a new clinica...
SOX11 as a potential prognostic biomarker in hepatocellular carcinoma linked to immune infiltration and ferroptosis
Hongyu Chen, Qiangguo Ao, Yueling Wang, Yue Qian, Qingli Cheng, Wei Zhang
2024, 36(4): 378-397. doi: 10.21147/j.issn.1000-9604.2024.04.03
Abstract(2735) FullText HTML (2492) PDF 8138KB(127)
Abstract:
ObjectiveSOX11 is expressed in numerous malignancies, including hepatocellular carcinomas (HCC), but its oncogenic function has not been elucidated. Here, we performed a comprehensive bioinformatics analysis of the Liver Hepatocellular Carcinoma (LIH...
Efficacy and safety of dacomitinib as first-line treatment for advanced non-small cell lung cancer patients with epidermal growth factor receptor 21L858R mutation: A multicenter, case-series study in China
Shouzheng Wang, Jiayu Liu, Yan Wang, Ying Hu, Ziling Liu, Yu Yao, Li Liang, Yutao Liu, Lin Wang, Junling Li, Puyuan Xing
2024, 36(4): 398-409. doi: 10.21147/j.issn.1000-9604.2024.04.04
Abstract(1751) FullText HTML (1273) PDF 3232KB(36)
Abstract:
ObjectiveTo provide real-world evidence for the application of first-line dacomitinib treatment for epidermal growth factor receptor (EGFR) 21L858R mutant non-small cell lung cancer (NSCLC) patients in China and to explore the factors influencing the...
Neoadjuvant chemotherapy with capecitabine combined with oxaliplatin for mid-low locally advanced rectal cancer with negative mesorectal fascia: Long-term outcomes of a prospective trial (PKUCH-R03 trial)
Nan Chen, Minghe Zhao, Yunfeng Yao, Lin Wang, Yifan Peng, Tingting Sun, Tiancheng Zhan, Jun Zhao, Aiwen Wu
2024, 36(4): 410-420. doi: 10.21147/j.issn.1000-9604.2024.04.05
Abstract(1626) FullText HTML (1081) PDF 1671KB(38)
Abstract:
ObjectiveTo evaluate the safety and efficacy of neoadjuvant chemotherapy (NCT) in mid-low locally advanced rectal cancer with negative mesorectal fascia (MRF). MethodsThis prospective, single-arm phase II trial was designed and conducted at Peking Un...
Review Article
Immune status and combined immunotherapy progression in Kirsten rat sarcoma viral oncogene homolog (KRAS)-mutant tumors
Dongsheng He, Rilan Bai, Naifei Chen, Jiuwei Cui
2024, 36(4): 421-441. doi: 10.21147/j.issn.1000-9604.2024.04.06
Abstract(1855) FullText HTML (1148) PDF 1921KB(37)
Abstract:
Kirsten rat sarcoma viral oncogene homolog (KRAS) is the most frequently mutated oncogene, occurring in various tumor types. Despite extensive efforts over the past 40 years to develop inhibitors targeting KRAS mutations, resistance to these inhibito...
Potential value of detection of minimal residual disease in colorectal cancer following radical resection
Wenji Pu, Fang Chen, Yuan Tang, Yanling Qu, Yunzhu Han, Jiandong Zha, Jing Jin, Fengming Kong
2024, 36(4): 442-454. doi: 10.21147/j.issn.1000-9604.2024.04.07
Abstract(1957) FullText HTML (1302) PDF 1345KB(32)
Abstract:
Although there has been significant advancement in the identification and management of colorectal cancer (CRC) in recent years, there is still room for improvement in the current standard treatment regimen. One area of concern is the lack of reliabl...